For PatientsPrescribing Information Important Safety Information
For US Healthcare
Professionals
ONCASPAR (pegaspargase) is indicated as a component of multi-agent chemotherapeutic regimen for treatment of patients with:
  • First-line acute lymphoblastic leukemia (ALL)
  • ALL and hypersensitivity to native forms of L-asparaginase
 
Important Safety Information
ONCASPAR® should not be given to people who have had:
  • History of serious allergic reactions to ONCASPAR
  • History of serious thrombosis with prior L-asparaginase therapy
  • History of pancreatitis with prior L-asparaginase therapy
  • History of serious hemorrhagic events with prior L-asparaginase therapy

See Full Important Safety Information

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Indication and Usage

ONCASPAR (pegaspargase) is indicated as a component of multi-agent chemotherapeutic regimen for treatment of patients with:
• First-line acute lymphoblastic leukemia (ALL)
• ALL and hypersensitivity to native forms of L-asparaginase

Detailed Important Safety Information
CONTRAINDICATIONS
• History of serious allergic reactions to ONCASPAR
• History of serious thrombosis with prior L-asparaginase therapy
• History of pancreatitis with prior L-asparaginase therapy
• History of serious hemorrhagic events with prior L-asparaginase therapy

WARNINGS and PRECAUTIONS
Anaphylaxis and Serious Allergic Reactions: Anaphylaxis or serious allergic reactions can occur; therefore, patients should be observed for one hour after administration. Discontinue ONCASPAR in patients with serious allergic reactions.
Thrombosis: Serious thrombotic events, including sagittal sinus thrombosis can occur. Discontinue ONCASPAR in patients with serious thrombotic events.
Pancreatitis: Pancreatitis can occur. Evaluate patients with abdominal pain for evidence of pancreatitis. Discontinue ONCASPAR in patients with pancreatitis.
Glucose Intolerance: Glucose intolerance can occur. In some cases, glucose intolerance is irreversible. Monitor serum glucose.
Coagulopathy: Increased prothrombin time, increased partial thromboplastin time, and hypofibrinogenemia can occur. Monitor coagulation parameters at baseline and periodically during and after treatment.
Hepatotoxicity: Hepatotoxicity and abnormal liver function can occur. Perform appropriate monitoring.

ADVERSE REACTIONS
The most common adverse reactions with ONCASPAR (≥2%) are allergic reactions (including anaphylaxis), hyperglycemia, pancreatitis, central nervous system (CNS) thrombosis, coagulopathy, hyperbilirubinemia, and elevated transaminases.
Hyperlipidemia (hypercholesterolemia and hypertriglyceridemia) has been reported in patients exposed to ONCASPAR.
Please click here for Full Prescribing Information.

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©2018 Shire US Inc., Lexington, MA 02421. All rights reserved. 1-800-828-2088. SHIRE and the Shire logo are registered trademarks of Shire Pharmaceutical Holdings Ireland Limited or its affiliates. ONCASPAR is a registered trademark of Baxalta Incorporated, a wholly owned, indirect subsidiary of Shire plc.
S34210 07/18

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ONCASPAR Home
For US Healthcare Professionals
ONCASPAR (pegaspargase) is indicated as a component of multi-agent chemotherapeutic regimen for treatment of patients with:
  • First-line acute lymphoblastic leukemia (ALL)
  • ALL and hypersensitivity to native forms of L-asparaginase
Important Safety Information
ONCASPAR® should not be given to people who have had:
  • History of serious allergic reactions to ONCASPAR
  • History of serious thrombosis with prior L-asparaginase therapy
  • History of pancreatitis with prior L-asparaginase therapy
  • History of serious hemorrhagic events with prior L-asparaginase therapy
See Full Important Safety Information
Indication and Usage
ONCASPAR (pegaspargase) is indicated as a component of multi-agent chemotherapeutic regimen for treatment of patients with:
Detailed Important Safety Information
CONTRAINDICATIONS
WARNINGS and PRECAUTIONS
Anaphylaxis and Serious Allergic Reactions: Anaphylaxis or serious allergic reactions can occur; therefore, patients should be observed for one hour after administration. Discontinue ONCASPAR in patients with serious allergic reactions.
Thrombosis: Serious thrombotic events, including sagittal sinus thrombosis can occur. Discontinue ONCASPAR in patients with serious thrombotic events.
Pancreatitis: Pancreatitis can occur. Evaluate patients with abdominal pain for evidence of pancreatitis. Discontinue ONCASPAR in patients with pancreatitis.
Glucose Intolerance: Glucose intolerance can occur. In some cases, glucose intolerance is irreversible. Monitor serum glucose.
Coagulopathy: Increased prothrombin time, increased partial thromboplastin time, and hypofibrinogenemia can occur. Monitor coagulation parameters at baseline and periodically during and after treatment.
Hepatotoxicity: Hepatotoxicity and abnormal liver function can occur. Perform appropriate monitoring.
ADVERSE REACTIONS

The most common adverse reactions with ONCASPAR (≥2%) are allergic reactions (including anaphylaxis), hyperglycemia, pancreatitis, central nervous system (CNS) thrombosis, coagulopathy, hyperbilirubinemia, and elevated transaminases.
Hyperlipidemia (hypercholesterolemia and hypertriglyceridemia) has been reported in patients exposed to ONCASPAR.
Please click here for Full Prescribing Information.

Shire Logo
Privacy Notice
Legal Disclaimers
Shire Corporate Website
ONCASPAR Order Form
Contact Us
References
©2018 Shire US Inc., Lexington, MA 02421. All rights reserved. 1-800-828-2088. SHIRE and the Shire logo are registered trademarks of Shire Pharmaceutical Holdings Ireland Limited or its affiliates. ONCASPAR is a registered trademark of Baxalta Incorporated, a wholly owned, indirect subsidiary of Shire plc.
S34210 07/18