Servier Pharmaceuticals LLC has recently acquired ONCASPAR® (pegaspargase) from Shire. Cardinal Health Specialty Pharmaceutical Distribution (SPD) will be the exclusive specialty distributor for ONCASPAR.

If you already have a Cardinal Health SPD account, please see detailed ordering and product information below and contact Cardinal Health SPD directly with any questions. For those who are new to working with Cardinal Health SPD, please call 866.476.1340 and ask for help with setting up an account.

Ordering Information:


This product will be available to order via OrderExpress: orderexpress.cardinalhealth.com
or Specialty Online: specialtyonline.cardinalhealth.com


Call 1.866.476.1340 to place an order by phone

Product Ordering Information:

Description Strength/Size Supplier NDC Number CIN
750 IU/mL
3750 IU/5mL single-dose vial
Servier 7269495401 5606769



  • History of serious hypersensitivity reactions, including anaphylaxis, to ONCASPAR or to any of the excipients.
  • History of serious thrombosis with prior L-asparaginase therapy.
  • History of pancreatitis, including pancreatitis related to prior L-asparaginase therapy.
  • History of serious hemorrhagic events with prior L-asparaginase therapy.
  • Severe hepatic impairment.


Anaphylaxis and Serious Hypersensitivity Reactions: Anaphylaxis and serious hypersensitivity reactions can occur. The risk ofserious hypersensitivity reactions is higher in patients with known hypersensitivity to E. coli derived L-asparaginase formulations. Observe patients for 1 hour after administration in a setting with resuscitation equipment and other agents necessary to treat anaphylaxis. Discontinue ONCASPAR in patients with serious hypersensitivity reactions.

Please click here for Full Prescribing Information.

Thrombosis: Serious thrombotic events, including sagittal sinus thrombosis, can occur. Discontinue ONCASPAR in patients with serious thrombotic events.

Pancreatitis: Pancreatitis can occur. Fatal outcomes have been reported. Inform patients of the signs and symptoms of pancreatitis. Discontinue ONCASPAR in patients where pancreatitis is suspected. If pancreatitis is confirmed, do not resume ONCASPAR.

Glucose Intolerance: Glucose intolerance can occur. In some cases, glucose intolerance is irreversible. Monitor serum glucose.

Hemorrhage: Increased prothrombin time, increased partial thromboplastin time, and hypofibrinogenemia can occur. Evaluate patients with signs and symptoms of hemorrhage with coagulation parameters including PT, PTT, and fibrinogen. Consider appropriate replacement therapy in patients with severe or symptomatic coagulopathy.

Hepatotoxicity: Hepatotoxicity and abnormal liver function can occur. Evaluate bilirubin and transaminases at least weekly during cycles of treatment through at least 6 weeks after the last dose. In the event of serious liver toxicity, discontinue ONCASPAR.


The most common grade 3 and 4 adverse reactions with ONCASPAR (>5%) included hypoalbuminemia, elevated transaminase, febrile neutropenia, hypertriglyceridemia, hyperglycemia, bilirubin increased, pancreatitis, abnormal clotting studies, embolic and thrombotic events, and hypersensitivity.